Job Description

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose to relieve suffering for people with great needs.

What We Do

Neurocrine Biosciences is a leading neurosciencefocused, biopharmaceutical company dedicated to discovering and developing lifechanging treatments for patients with underaddressed neurological, neuroendocrine, and neuropsychiatric disorders. The companys diverse portfolio includes FDAapproved treatments for tardive dyskinesia, chorea associated with Huntingtons disease, classic congenital adrenal hyperplasia, endometriosis, and uterine fibroids, as well as a robust pipeline of multiple compounds in midto latephase clinical development across our core therapeutic areas. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, and Facebook.

About the Role

Responsible for devising the medicinal chemistry strategy on projects. May lead or colead multidisciplinary project teams to advance discovery programs to key milestones. Provides expertise in medicinal chemistry principles, complex small molecule synthesis, purification, and data analysis. Supervises and mentors both internal direct reports and external CROs towards hypothesisdriven chemistry strategies. Monitors and evaluates completion of tasks and projects. Contributes to development of policies and department strategies.

Your Contributions (include, but are not limited to)

• Leads projects and initiatives in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification.
• Distills complicated, multidimensional data to clear hypotheses and new experimental directions.
• Imports new principles/concepts to develop useful new experimental approaches.
• Researches external intellectual property relevant to project(s) and areas of pursuit.
• Contributes substantively to patent and publication preparation.
• Responsible for designing, planning, and conducting synthesis of analog libraries as well as communicating results to the project or program team.
• Participates in a multidisciplinary team committed to the continuous improvement of the lead optimization process as well as the expeditious identification of development compounds.
• Plans and manages projects. Represents Medicinal Chemistry on crossfunctional teams. Maintains accountability for deliverables and progress for projects.
• Independently designs, plans and executes activities toward the goals of one or more Medicinal Chemistry projects to support lead generation through preclinical activities.
• Supervises laboratory work and/or lab personnel and ensures safe laboratory practices.
• Creates and implements novel ideas in Medicinal Chemistry.
• Provides effective supervision of laboratory personnel and guidance for their professional development.
• Builds and enhances internal and external professional relationships.
• Other duties as assigned.

Requirements

• BS/BA in Chemistry and 10+ years of experience in chemistry, parallel synthesis, lab automation, and purification in the optimization of lead compounds OR
• MS/MA in Chemistry preferred and 8+ years of industrial experience OR
• PharmD or PhD in Chemistry preferred and 5+ years of industrial experience.
• Advanced knowledge of complex organic synthesis, parallel synthesis, data analysis, lab automation, and purification in the optimization of lead compounds.
• Thorough understanding of medicinal chemistry and a welldeveloped understanding of current literature.
• Excellent interpersonal skills with strong oral and written communication abilities.
• Excellent laboratory and productivity skills.
• Demonstration of crossfunctional understanding related to drug development.
• Excellent communication skills and ability to collaborate in a matrix environment are required.
• Strong track record of innovation demonstrated through patents and publications is necessary.
• Assimilates data and research findings outside of Neurocrine for application to new scientific projects.
• Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas.
• May develop an understanding of other areas and related dependencies.
• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools.
• Ability to work as part of and lead multiple teams.
• Exhibits leadership skill and ability, typically leads lower levels and/or indirect teams.
• Excellent computer skills.
• Excellent communications, problemsolving, analytical thinking skills.
• Sees broader picture, impact on multiple programs, teams and/or departments.
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency.
• Excellent project management skills.

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EEO Statement

Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications dont line up to exactly what we have outlined in the job description.

The annual base salary we reasonably expect to pay is $128,200.00$185,900.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equitybased longterm incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

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